Supramedullary Afferents to the Nucleus Raphe Magnus in the Rat: A Study Using Transcannula HRP-gel and Autoradiography Techniques
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Analgesic effect of morphine microinjected into the nucleus raphe magnus after electrolytic lesion of nucleus cuneiformis in tail-flick and formalin tests in rat
Introduction: The antinociceptive effect of morphine is, in part, mediated through the activation of a descending pathway. One of the major components of this pathway is the nucleus raphe magnus (NRM). Our previous study demonstrated the involvement of NRM in the analgesic effect of morphine microinjected into the nucleus cuneiformis (NCF) in a descending manner. The aim of the current study...
متن کاملEffect of Specific Lesion of Non Serotonergic Pathway on Neurons of Nucleus Raphe Magnus Morphology in Rat
Purpose: The nucleus raphe magnus (NRM) is a medullary nucleus containing serotonergic and non serotonergic neurons, both of which densely project to spinal cord. The goal of this study was to determine the role of these non serotonergic neurons in pain perception and their cytological changes after the specific lesion of bulbo-spinal serotonergic pathway. Materials and Methods: Male rats were...
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In order to understand the function of mammalians serotonin system, we have to know the anatomical structure, because physiological changes are influenced through the anatomical changes. A number of thalamic nuclei are associated with functions known to be influenced by serotonergic input in brainstem, among them mediodorsal thalamic nucleus has relationship with limbic system and prefrontal co...
متن کاملReversible Inactivation and Excitation of Nucleus Raphe Magnus Can Modulate Tail Blood Flow of Male Wistar Rats in Response to Hypothermia
Background: The nucleus raphe magnus (NRM) is involved in thermoregulatory processing. There is a correlation between changes in the firing rates of the cells in the NRM and the application of the peripheral thermal stimulus. Introduction: we examined the effect of reversible inactivation and excitation of NRM on mechanisms involved in tail blood flow (TBF) regulation in hypothermia. Methods: H...
متن کاملEffects of Electrolytic Lesions of the Ventrolateral Periaqueductal Gray and Nucleus Raphe Magnus on Morphine – Induced Antinociception in the Nucleus Cuneiformi
A B S T R A C TIntroduction: The nucleus cuneiformis (NCF) and ventrolateral periaqueductal gray (vlPAG), two adjacent areas, mediate the central pain modulation and project to the nucleus raphe magnus (NRM). Methods: This study examined whether the antinociceptive effect of morphine microinjected into the NCF is influenced by inactivation of vlPAG and NRM in rats. Animals were bilaterally micr...
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